Fast and robust measurement of microstructural dimensions using temporal diffusion spectroscopy
نویسندگان
چکیده
منابع مشابه
Fast and robust measurement of microstructural dimensions using temporal diffusion spectroscopy.
Mapping axon sizes non-invasively is of interest for neuroscientists and may have significant clinical potential because nerve conduction velocity is directly dependent on axon size. Current approaches to measuring axon sizes using diffusion-weighted MRI, e.g. q-space imaging with pulsed gradient spin echo (PGSE) sequences usually require long scan times and high q-values to detect small axons ...
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Mapping axon diameter is of interest for the potential diagnosis and monitoring of various neuronal pathologies. Advanced diffusion-weighted MRI methods have been developed to measure mean axon diameters non-invasively, but suffer major drawbacks that prevent their direct translation into clinical practice, such as complex non-linear data fitting and, more importantly, long scanning times that ...
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PURPOSE A new approach has been developed to quantify cell sizes and intracellular volume fractions using temporal diffusion spectroscopy with diffusion-weighted acquisitions. METHODS Temporal diffusion spectra may be used to characterize tissue microstructure by measuring the effects of restrictions over a range of diffusion times. Oscillating gradients have been used previously to probe var...
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Diffusion MRI provides a non-invasive means to characterize tissue microstructure at varying length scales. Apparent diffusion coefficients (ADCs) of tissue water may be measured at relatively long diffusion times with conventional pulsed gradient spin echo (PGSE) methods, or at much shorter effective diffusion times using oscillating gradient spin echo (OGSE) methods. The manner in which ADC d...
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BACKGROUND Fluorescence correlation spectroscopy (FCS) provides information about translational diffusion of fluorescent molecules in tiny detection volumes at the single-molecule level. In normal states, cartilage tissue lacks vascularity, so chondrocyte metabolism depends on diffusion for molecular exchanges. The abundant extracellular matrix (ECM) of cartilage is maintained by a limited numb...
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ژورنال
عنوان ژورنال: Journal of Magnetic Resonance
سال: 2014
ISSN: 1090-7807
DOI: 10.1016/j.jmr.2014.02.007